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Pattern of Pseudomonas aeruginosa drug resistance in Tabriz Children Hospital
Z Ghorashi1, N Nezami, R Ghotaslou
1Department of Pediatrics, Tabriz Children Hospital, Tabriz University (Medical Sciences), Tabriz, Eastern Azerbaijan, Iran.
Abstract:
Regarding the different reports about increasing drug resistance of Pseudomonas, this study was done in Tabriz Pediatric Medical Center. In a cross sectional study, during 3 years, 84 positive culture of pseudomonas were obtained from the records of microbiology laboratory. Information about the patients and pattern of drug resistance were analyzed statistically. 81.9% of patients were below 2 years of age and all of them had one or more medical intervention. Most of the positive cultures were isolated from bronchial and eye discharges. Eighty one percent of positive cultures were from intensive care unit and neonatal wards. Resistance to Ampicillin, Ceftizoxime, Cotrimoxasol and Cefotoxime has been more than 95%. Resistance to Ceftazidime was seen in 50% and lowest resistance was to Ciprofloxacin. At present time Ciprofloxacin is relatively effective antibiotic for Pseudomonas infection. Since, there is increasing resistance to this drug and limited use of this drug in children, newer antibiotic discs should be used in antibiogram.
Insights
Pseudomonas aeruginosa exhibits high drug resistance, particularly in young children requiring medical intervention. Ciprofloxacin remains relatively effective, but increasing resistance necessitates updated antibiotic susceptibility testing for Pseudomonas infections.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pediatric Medicine
Background:
- Increasing reports of drug resistance in Pseudomonas aeruginosa infections.
- Pseudomonas aeruginosa is a significant opportunistic pathogen, especially in healthcare settings.
Purpose of the Study:
- To investigate the drug resistance patterns of Pseudomonas aeruginosa in a pediatric population.
- To identify effective antibiotics for treating Pseudomonas infections in children.
Main Methods:
- Cross-sectional study analyzing 84 positive Pseudomonas cultures over 3 years.
- Data collected from patient records at Tabriz Pediatric Medical Center.
- Statistical analysis of patient demographics and antibiotic resistance patterns.
Main Results:
- 81.9% of patients were under 2 years old, often with prior medical interventions.
- Positive cultures predominantly from bronchial and eye discharges, with 81% from intensive care and neonatal units.
- High resistance (>95%) to Ampicillin, Ceftizoxime, Cotrimoxasol, and Cefotoxime.
- 50% resistance to Ceftazidime; lowest resistance observed with Ciprofloxacin.
Conclusions:
- Ciprofloxacin is currently a relatively effective antibiotic for Pseudomonas infections in this pediatric cohort.
- The increasing resistance to Ciprofloxacin and its limited use in children highlight the need for updated antibiotic susceptibility testing.
- Regular review and updating of antibiotic discs used in antibiograms are crucial for effective treatment strategies.
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