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Related Experiment Video

Updated: Jun 8, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Pathological aspects of lipid peroxidation.

Anne Negre-Salvayre¹, Nathalie Auge, Victoria Ayala

¹INSERM I2MR-858, IFR-150, Avenue J Poulhès, BP 84225, Toulouse, France. anne.negre-salvayre@inserm.fr

Free Radical Research

|September 15, 2010

Summary

Lipid peroxidation (LPO) product accumulation drives cellular dysfunction in aging and oxidative stress diseases. This review covers LPO

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Area of Science:

Biochemistry
Pathophysiology
Gerontology

Background:

Lipid peroxidation (LPO) product accumulation is a key factor in cellular dysfunction.
LPO is implicated in aging and various oxidative stress-related diseases.
Understanding LPO's role is crucial for disease management and aging research.

Purpose of the Study:

To review the current evidence linking LPO to pathological processes.
To evaluate LPO's role in the pathophysiology of aging and oxidative stress-linked diseases.
To discuss LPO's involvement in specific conditions like neurodegeneration, diabetes, atherosclerosis, pre-eclampsia, renal and liver diseases, and cancer.

Main Methods:

Literature review
Analysis of existing data
Synthesis of current evidence

Main Results:

LPO accumulation contributes to tissue and cellular dysfunction.
Evidence strongly implicates LPO in aging, neurodegenerative diseases, diabetes, and atherosclerosis.
LPO is involved in pre-eclampsia, renal/liver diseases, and cancer development.

Conclusions:

Lipid peroxidation is a significant contributor to aging and numerous diseases.
Targeting LPO may offer therapeutic strategies for age-related and oxidative stress conditions.
Further research into LPO's multifaceted roles is warranted.