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Related Experiment Video

Updated: Jun 8, 2026

Generation of Human Kidney Tubuloids from Tissue and Urine

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

Thymosin beta-10 expression in developing human kidney.

Clara Gerosa¹, Daniela Fanni, Sonia Nemolato

¹Department of Pathology, University of Cagliari, Cagliari, Italy.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|September 15, 2010

Summary

Thymosin beta-10 (Tβ10) peptide is expressed in developing human kidneys, particularly in tubular structures during early renal embryogenesis. This study confirms Tβ10

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Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

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Published on: April 22, 2011

Area of Science:

Developmental Biology
Renal Physiology
Molecular Biology

Background:

Thymosin beta-10 (Tβ10) is a peptide involved in crucial cellular functions.
Previous studies indicated high Tβ10 gene expression in embryonic human brain and kidney.

Purpose of the Study:

To investigate Thymosin beta-10 (Tβ10) expression in preterm human kidneys during renal embryogenesis.
To confirm Tβ10 peptide localization at the tissue level during kidney development.

Main Methods:

Immunocytochemistry was employed to analyze Tβ10 expression.
Kidney samples from fetuses, preterm infants, and term newborns were examined.

Main Results:

Tβ10 immunoreactivity was found in 20 out of 22 examined kidneys.
The peptide was primarily localized in proximal and distal tubular structures, with some presence in ductal cell cytoplasm and nuclei.
Focal Tβ10 reactivity was observed in glomeruli and during active glomerulogenesis in comma-shaped and S-shaped bodies.

Conclusions:

This study provides the first evidence of Thymosin beta-10 (Tβ10) expression in the developing human kidney.
Tβ10 is mainly localized in proximal and distal tubules during early kidney development.
Further research is required to elucidate the specific role of Tβ10 in kidney embryogenesis.