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Updated: Jun 8, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization
Zhi Liang1, Meng Xu, Maikun Teng
1Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science, University of Science & Technology of China, Hefei, Anhui, China. liangzhi@ustc.edu.cn
Abstract:
We investigated what roles coevolution plays in shaping yeast protein interaction network (PIN). We found that the extent of coevolution between two proteins decreases rapidly as their interacting distance on the PIN increases, suggesting coevolutionary constraint is a short-distance force at the molecular level. We also found that protein-protein interactions (PPIs) with strong coevolution tend to be enriched in interconnected clusters, whereas PPIs with weak coevolution are more frequently present at inter-cluster region. The findings indicate the close relationship between coevolution and modular organization of PINs, and may provide insights into evolution and modularity of cellular networks.
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