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Preliminary experience with clevidipine in the pediatric population
1Department of Pediatrics, University of Missouri, Columbia, MO, USA.
Journal of Intensive Care Medicine
|September 15, 2010
Summary
Clevidipine, a novel antihypertensive, shows promise in pediatric patients for managing blood pressure during surgery. This preliminary study indicates its efficacy and safety in adolescents, with manageable side effects.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Pediatric Anesthesiology
Background:
- Clevidipine is a third-generation dihydropyridine calcium channel antagonist known for its vasodilatory effects and ultrashort half-life.
- Clinical experience with clevidipine is primarily documented in adult cardiac surgery patients.
- Limited data exists regarding clevidipine's use in pediatric populations.
Purpose of the Study:
- To evaluate the preliminary experience and efficacy of clevidipine in pediatric patients.
- To assess clevidipine's safety and effectiveness for blood pressure management in adolescents undergoing surgery.
Main Methods:
- Retrospective review of 10 pediatric patients (ages 9-18) who received clevidipine.
- Clevidipine administered for perioperative hypertension, controlled hypotension, and improved perfusion.
- Infusion rates started at 0.5-1 μg/kg/min, titrated up to 3.5 μg/kg/min.
Main Results:
- Clevidipine effectively controlled blood pressure in pediatric surgical patients.
- No excessive hypotension observed; 2 patients required metoprolol for reflex tachycardia.
- One patient experienced an elevated triglyceride level.
Conclusions:
- Clevidipine demonstrates efficacy for perioperative blood pressure control in pediatric patients.
- The drug appears safe for use in adolescents, with manageable adverse events.
- Further research is warranted to establish clevidipine's role in pediatric cardiovascular care.
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