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Related Experiment Video

Updated: Jun 8, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Type I interferon: friend or foe?

Giorgio Trinchieri¹

¹Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. trinchig@mail.nih.gov

The Journal of Experimental Medicine

|September 15, 2010

Summary

Type I interferons (IFN) are crucial for antiviral defense. However, their complex roles in bacterial infections, shock, autoimmunity, and cancer require further investigation beyond their known antiviral functions.

Area of Science:

Immunology
Virology
Microbiology

Background:

Type I interferons (IFN) are well-established critical mediators of antiviral immunity.
Decades of research have elucidated the significant role of type I IFNs in combating viral infections.

Purpose of the Study:

To explore the less-defined roles of type I IFNs in non-viral immunological contexts.
To investigate the complex involvement of type I IFNs in bacterial infections, shock, autoimmunity, and cancer.

Main Methods:

This study reviews existing literature and discusses emerging evidence.
Analysis of immunological pathways and cellular responses related to type I IFN signaling.

Main Results:

The role of type I IFNs extends beyond viral infections, impacting other immune responses.

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Last Updated: Jun 8, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

Emerging data suggest a complex and multifaceted involvement of type I IFNs in bacterial infections, shock, autoimmunity, and cancer.

Conclusions:

Type I IFNs possess a broader immunological scope than previously understood.
Further research is essential to fully comprehend the intricate functions of type I IFNs in diverse pathological conditions.