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Optimization of 99Mo measurement in 99mTc eluate samples using a scintillation detection system
Ana Letícia A Dantas1, Bianca S Ribeiro, Raphael Sancho S Souza
1Instituto de Radioproteção e Dosimetria (IRD-CNEN), Av. Salvador Allende, s/n-22780-160, Rio de Janeiro, Brazil. adantas@ird.gov.br
Health Physics
|September 15, 2010
Summary
This study optimized a method to detect molybdenum-99 (99Mo) impurity in technetium-99m (99mTc) eluates. The validated technique accurately measures 99Mo levels below international safety limits for nuclear medicine.
Area of Science:
- Nuclear Medicine
- Radiochemistry
- Analytical Chemistry
Background:
- Molybdenum-99 (99Mo) can contaminate technetium-99m (99mTc) eluates during generator elution, posing a radionuclidic impurity risk.
- International Atomic Energy Agency (IAEA) guidelines stipulate a maximum 99Mo/99mTc activity ratio of 0.015% at patient administration.
Purpose of the Study:
- To optimize and validate a sensitive methodology for quantifying 99Mo activity in 99mTc eluates.
- To ensure compliance with international safety standards for radiopharmaceutical purity.
Main Methods:
- Utilized a NaI(Tl) 8"x4" scintillation detector to establish efficiency curves.
- Validated the developed methodology by measuring a standard 99Mo solution.
Main Results:
- The optimized methodology demonstrated high sensitivity for 99Mo detection.
- Quantifiable 99Mo levels were detected below the internationally accepted limits.
Conclusions:
- The developed technique is suitable for routine quality control of 99mTc eluates.
- This method ensures patient safety by verifying the absence of significant 99Mo contamination.
