Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling and investigating the interactive role of fluid velocity and pore pressure within the lacunar-canalicular system in load-induced osteogenesis.

Bone·2026
Same author

Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration.

International journal of oral science·2026
Same author

Predicting cortical bone resorption in the mouse tibia under disuse conditions caused by transient muscle paralysis.

Scientific reports·2025
Same author

Genomic determinants of biological age estimated by deep learning applied to retinal images.

GeroScience·2025
Same author

Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.

JAMA cardiology·2024
Same author

Derivation, validation, and prediction of loading-induced mineral apposition rates at endocortical and periosteal bone surfaces based on fluid velocity and pore pressure.

Bone reports·2023
Same journal

Another 10 years of PLOS Computational Biology: A data-driven reflection on trends in genomics research.

PLoS computational biology·2026
Same journal

Mobility data resolution needed to inform predictive models of spatial epidemic spread from mobile phone data.

PLoS computational biology·2026
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Rescuing loading induced bone formation at senescence.

Sundar Srinivasan1, Brandon J Ausk, Jitendra Prasad

  • 1Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America. sundars@u.washington.edu

Plos Computational Biology
|September 15, 2010
PubMed
Summary
This summary is machine-generated.

Osteoporosis treatments need to be safe, effective, and affordable. Supplementing exercise with Cyclosporin A rescues bone formation in aged animals, offering a potential low-cost therapy for the elderly.

More Related Videos

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Related Experiment Videos

Last Updated: Jun 8, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Area of Science:

  • Biomedical Engineering
  • Cellular Biology
  • Gerontology

Background:

  • Osteoporosis incidence is rising globally, necessitating anabolic treatments.
  • Age-related deficits in mechanotransduction reduce exercise efficacy for elderly bone health.
  • Cellular signaling during rare events may control tissue adaptation.

Purpose of the Study:

  • To model age-related cellular signaling deficits in bone formation.
  • To identify therapeutic targets to counteract diminished bone anabolism in senescence.
  • To test a novel intervention combining mechanical stimuli and pharmaceutical treatment.

Main Methods:

  • Developed an agent-based model of calcium/NFAT signaling in bone cells.
  • Simulated bone formation responses to various loading stimuli in young and aged animals.
  • Implemented an in vivo intervention based on model predictions.

Main Results:

  • The model accurately described periosteal bone formation across age groups and loading conditions.
  • Identified age-related alterations in signaling pathways contributing to reduced bone formation.
  • Demonstrated that low-dose Cyclosporin A rescues loading-induced bone formation in aged animals.

Conclusions:

  • Real-time cellular signaling dynamics are crucial for bone adaptation to mechanical stimuli.
  • In silico analysis identified a novel therapeutic strategy with clinical potential.
  • Combining mechanical stimuli with Cyclosporin A may offer an inexpensive therapy to augment bone mass in the elderly.