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Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Layers of the Heart Wall01:15

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Ferrocement01:30

Ferrocement

Ferro-cement is a distinctive construction material that represents an innovative variant of reinforced concrete, characterized by its unique composition and the method by which it is formed. Unlike standard reinforced concrete, which relies on larger steel bars for reinforcement, ferro-cement utilizes densely packed layers of mesh or fine rods, fully encased in cement mortar. This composition allows for the creation of structures that are significantly thinner and more flexible than their...
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Anatomy of the Heart01:20

Anatomy of the Heart

The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.

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Related Experiment Video

Updated: Jun 8, 2026

Coronary Angiography During Ex-Situ Heart Perfusion in a Porcine Model
06:25

Coronary Angiography During Ex-Situ Heart Perfusion in a Porcine Model

Published on: July 12, 2024

Coeur en sabot.

F Aziz1, M Abed

  • 1Department of Internal Medicine, MSS M, Jersey City Campus, New Jersey, USA. Fahadaziz.md@gmail.com

Cardiovascular Journal of Africa
|September 15, 2010
PubMed
Summary
This summary is machine-generated.

Tetralogy of Fallot (TOF), a congenital heart defect, rarely allows survival to adulthood without surgery. This case highlights a 39-year-old woman with uncorrected TOF, offering insights into late outcomes.

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Last Updated: Jun 8, 2026

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Area of Science:

  • Cardiology
  • Congenital Heart Disease
  • Medical Case Reports

Background:

  • Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease.
  • Survival into adulthood without surgical correction for TOF is rare.

Observation:

  • A 39-year-old woman with undiagnosed Tetralogy of Fallot presented with congestive heart failure.
  • Her longevity was attributed to slow progression of pulmonary artery stenosis and left ventricular hypertrophy.

Findings:

  • Uncorrected TOF patients rarely survive past their 40s (less than 3%).
  • Late operative repair remains a viable option for older patients with uncorrected TOF.

Implications:

  • This case offers valuable insights into the long-term outcomes of older individuals with uncorrected Tetralogy of Fallot.
  • It underscores the potential for late surgical intervention in select adult TOF patients.