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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
What is the Immune System?01:38

What is the Immune System?

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Humoral Immune Responses01:36

Humoral Immune Responses

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Related Experiment Video

Updated: Jun 8, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

The complement system.

J Vidya Sarma1, Peter A Ward

  • 1Department of Pathology, The University of Michigan Medical School, 1301 Catherine Rd., Box 5602, Ann Arbor, MI 48109-5602, USA.

Cell and Tissue Research
|September 15, 2010
PubMed
Summary
This summary is machine-generated.

The complement system is a key part of host defense and inflammation. Dysregulation of this protein network contributes to diseases like lupus and asthma.

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Last Updated: Jun 8, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

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Published on: February 5, 2010

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

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Published on: January 29, 2014

Measuring the 50% Haemolytic Complement (CH50) Activity of Serum
08:26

Measuring the 50% Haemolytic Complement (CH50) Activity of Serum

Published on: March 29, 2010

Area of Science:

  • Immunology
  • Biochemistry

Background:

  • The complement system is a crucial component of the innate immune system.
  • It comprises a network of proteins involved in host defense and inflammatory processes.
  • Complement activation leads to pathogen opsonization, phagocytosis, and cell lysis.

Purpose of the Study:

  • To provide an overview of the complement system.
  • To elucidate the dual role of complement in inflammatory responses.
  • To understand the implications of complement dysregulation in disease.

Main Methods:

  • This is a review article.
  • It synthesizes existing knowledge on complement biology.
  • Literature search and analysis of complement functions.

Main Results:

  • Complement activation is essential for effective pathogen clearance.
  • Inappropriate complement activation or deficiency is linked to autoimmune and inflammatory diseases.
  • The system exhibits both protective and detrimental effects during inflammation.

Conclusions:

  • Understanding the complement system's complex roles is vital.
  • Targeting complement pathways may offer therapeutic strategies for inflammatory diseases.
  • Further research is needed to fully harness complement's potential in medicine.