Two new phenolic glycosides from Inula cappa

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Medicinal Chemistry

Background:

• Inula cappa is a traditional Chinese medicinal herb with a history of use in various remedies.
• The chemical constituents of Inula cappa are not fully explored, presenting opportunities for new discoveries.
• Phenolic glycosides are a class of compounds known for diverse biological activities.

Purpose of the Study:

• To isolate and characterize novel compounds from Inula cappa.
• To contribute to the understanding of the phytochemical profile of Inula cappa.
• To identify potential bioactive molecules from traditional medicinal herbs.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation employing 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
• High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS) for accurate mass determination.

Main Results:

• Two new phenolic glycosides were successfully isolated from Inula cappa.
• Compound 1 was identified as syringic acid-4-O-α-L-rhamnoside.
• Compound 2 was identified as (-)-hydnocarpin-7-O-β-D-glucoside.
• The structures were confirmed through comprehensive spectroscopic analysis.

Conclusions:

• The study successfully identified two previously unknown phenolic glycosides from Inula cappa.
• The findings expand the knowledge of Inula cappa's chemical constituents.
• This research provides a basis for further investigation into the pharmacological properties of these novel compounds.