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Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
Published on: December 5, 2019
Inclusion of carboxyl function inside of cucurbiturils and its use in molecular switches
Viktor Kolman1, Petr Kulhanek, Vladimir Sindelar
1Department of Chemistry, Masaryk University, Kotlarska 2, 61137 Brno, Czech Republic.
Abstract:
We have prepared organic guest molecules in which two pyridinium rings are connected through an aromatic/aliphatic bridge bearing a carboxyl group. The supramolecular interactions between these guests and macrocyclic hosts cucurbit[7]uril (CB7) and cucurbit[8]uril (CB8) has been studied. We have demonstrated that the binding modes of the complexes depend on the type of central bridge present in the guest molecules and the size of the macrocycle. We have also showed that the binding mode between cucurbiturils and guests with aromatic bridges is pH independent. On the other hand, a guest containing an aliphatic bridge and CB7 formed a pseudorotaxane, which behaved as a pH-driven molecular switch.
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