[Study on risk factors of nonsyndromic cleft lip and palate in Chinese Guangdong population]
Related Experiment Video
Updated: Jun 8, 2026
Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
Shenyou Shu1, Shijie Tang, Shenrong Wu
1Cleft Lip & Palate Treatment Centre, Second Affiliated Hospital of Medical College, Shantou University, Shantou Guangdong 515041, PR China. shengyoushu2004@163.com
Insights
Genetic family history, abnormal maternal reproductive history, early pregnancy medication, and maternal stress are key risk factors for nonsyndromic cleft lip and palate (NSCLP) in Guangdong, China. Environmental interventions targeting these factors may help reduce NSCLP incidence.
Area of Science:
- Public Health
- Genetics
- Environmental Medicine
Background:
- Nonsyndromic cleft lip and palate (NSCLP) is a common congenital anomaly with multifactorial causes.
- Understanding the interplay of genetic and environmental factors is crucial for effective prevention strategies.
Purpose of the Study:
- To investigate environmental risk factors associated with NSCLP in the Chinese Guangdong population.
- To explore potential interactions among identified risk factors for NSCLP.
Main Methods:
- A hospital-based case-control study was conducted involving 105 NSCLP cases and 110 controls.
- Data on risk factors were collected via physician-administered questionnaires and analyzed using chi-square tests and multivariate unconditional logistic regression.
Main Results:
- Genetic family history (OR=4.210), abnormal maternal reproductive history (OR=2.494), early pregnancy medication (OR=3.488), and maternal stress (OR=3.416) were significant risk factors for NSCLP.
- Positive interactions were observed between genetic family history and abnormal maternal reproductive history, and between genetic family history and early pregnancy medication.
Conclusions:
- Specific environmental and genetic factors are significantly associated with NSCLP in the Guangdong population.
- Interventions targeting identified risk factors, such as maternal health and medication use during pregnancy, could potentially lower NSCLP incidence.
Objective:
To investigate the association between environmental factors and nonsyndromic cleft lip and palate (NSCLP), and to explore the interaction of main risk factors in Chinese Guangdong population.
Methods:
A hospital-based case-control study was used. NSCLP children were selected from Cleft Lip & Palate Treatment Centre of Second Affiliated Hospital of Medical College of Shantou University between September 2009 and March 2010 as cases. And controls were chosen from other departments in the same hospital during the same period. The parents of cases and controls were inquired regarding the risk factors and the answers were filled in a unification questionnaire by physicians. These data were analysed with chi-square test and multivariate unconditional logistic regression analysis.
Results:
A total of 105 cases and 110 controls with a mean age of 2.2 years and 3.0 years, respectively, were enrolled. Multivariate logistic regression analysis revealed that genetic family history (OR = 4.210, P = 0.039), mothers' abnormal reproductive history (OR = 2.494, P = 0.033), early pregnancy medication (OR = 3.488, P = 0.000), and maternal stress (OR = 3.416, P = 0.011) were risk factors. There were positive interactions between genetic family history and mothers' abnormal reproductive history as well as early pregnancy medication.
Conclusion:
Certain influencing factors including genetic family history, mothers' abnormal reproductive history, early pregnancy medication, and maternal stress are associated with NSCLP among Chinese Guangdong population. This study suggests that it may reduce the incidence rate of NSCLP through environmental intervention.
