Related Experiment Video
Updated: Jun 8, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
[Toxicogenomics in hazard assessment of chemicals]
Grazyna Kostka1, Monika Liszewska, Katarzyna Urbanek-Olejnik
1Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego-Państwowy Zakład Higieny, Warszawa. gkostka@pzh.gov.pl
Abstract:
Recent changes in the European legislation of chemicals suggest an urgent need for introduction of novel, alternative methods for testing chemical substances. Such possibility is offered by toxicogenomics--a scientific discipline combining knowledge from the field of toxicology, i.e., a science investigating the properties of toxic agents and the negative effects these agents exert on health and environment, with genomics, i.e., a science investigating the structure and function of genomes. New research strategies within the field of toxicology (transcriptomics, proteomics, metabolomics) offer conditions to assess the hazards associated with the effects of chemicals with both established and suspected toxic potentials.
Related Concept Videos
Toxicity Testing in Animals
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Mutagenicity and Carcinogenicity
Drug Toxicity: Dose-Dependent Reactions
Toxicokinetics: Overview

