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A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

Febrile seizures

Alok Hemal1, B P Kalra, Veena Gupta

  • 1Department of Paediatrics, Himalayan Institute of Medical Sciences, Dehradun 248140.

Journal of the Indian Medical Association
|September 16, 2010
PubMed

Insights

Febrile seizures are common in children and usually benign, with little risk of long-term harm or developing epilepsy. Treatments like anti-epileptic drugs don't prevent future epilepsy, shifting treatment approaches.

Area of Science:

  • Pediatrics
  • Neurology
  • Epilepsy

Background:

  • Febrile seizures affect 2-5% of US children, most commonly simple seizures.
  • Complex febrile seizures have focal onset, prolonged duration, or recurrence within one illness.
  • Risk factors for febrile seizures, recurrence, and epilepsy are identifiable.

Purpose of the Study:

  • To review the characteristics, risks, and management of febrile seizures in children.
  • To discuss the evolving approach to treating febrile seizures based on current evidence.

Main Methods:

  • Review of existing literature on febrile seizures.
  • Analysis of risk factors for recurrence and epilepsy development.
  • Evaluation of the efficacy of anti-epileptic drugs.

Main Results:

  • Febrile seizures carry minimal risk of mortality, morbidity, or detectable brain damage.
  • Recurrence is possible, but few children develop epilepsy.
  • Anti-epileptic drugs prevent recurrence but do not reduce the risk of subsequent epilepsy.

Conclusions:

  • Febrile seizures are generally benign with a low risk of long-term consequences.
  • The treatment paradigm for febrile seizures is shifting due to the limited impact of anti-epileptic drugs on epilepsy development.

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