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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Systemic therapy for melanoma.

Prasanth Ganesan1, Sameer Bakhshi

  • 1Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India.

The National Medical Journal of India
|September 16, 2010
PubMed
Summary
This summary is machine-generated.

Advanced melanoma has a poor prognosis, with chemotherapy often ineffective. Emerging immune-based and targeted therapies show promise for treating this advanced skin cancer.

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Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Advanced melanoma presents a significant clinical challenge with limited effective treatment options.
  • Conventional chemotherapy agents demonstrate low efficacy in treating advanced melanoma.
  • Melanoma exhibits unique responsiveness to immune-based and targeted therapies compared to other cancers.

Purpose of the Study:

  • To provide a comprehensive overview of current management strategies for advanced melanoma.
  • To highlight emerging systemic therapies for advanced melanoma.
  • To discuss the evolving landscape of melanoma treatment.

Main Methods:

  • Literature review of recent advancements in melanoma research.
  • Analysis of clinical trial data for novel therapies.
  • Synthesis of current treatment guidelines and expert opinions.

Main Results:

  • Immune-based therapies (e.g., checkpoint inhibitors) have shown significant clinical benefit.
  • Targeted therapies directed at specific mutations (e.g., BRAF inhibitors) offer new treatment avenues.
  • Combination strategies are being explored to enhance treatment efficacy.

Conclusions:

  • Emerging immune and targeted therapies represent a paradigm shift in advanced melanoma management.
  • Continued research is crucial for optimizing treatment protocols and improving patient outcomes.
  • The future of advanced melanoma treatment lies in personalized and innovative systemic approaches.