Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

Appendicitis-II: Diagnostic Studies and Management

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.

Pericarditis IV: Nursing Management

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Appendicitis

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Know the Approach; Don't Sell the Approach!: Commentary on an article by Wayne Hoskins, MBBS(Hons), PhD, FRACS, et al.: "Early Rate of Revision of Total Hip Arthroplasty Related to Surgical Approach. An Analysis of 122,345 Primary Total Hip Arthroplasties".

The Journal of bone and joint surgery. American volume·2020

Same author

CORR Insights®: Complications in Patients Undergoing Spinal Fusion After THA.

Clinical orthopaedics and related research·2018

Same author

CORR Insights®: Total hip arthroplasty performed in patients with residual poliomyelitis: does it work?

Clinical orthopaedics and related research·2013

Same author

Metal-on-metal surface replacement: a triumph of hope over reason: affirms.

Orthopedics·2011

Same author

Surface Roughness of CoCr and ZrO(2) Femoral Heads with Metal Transfer: A Retrieval and Wear Simulator Study.

International journal of biomaterials·2010

Same author

Early failure of a cross-linked polyethylene acetabular liner. A case report.

The Journal of bone and joint surgery. American volume·2008

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Unexplained pain after THR: what should i do?

John M Cuckler¹

¹Alabama Spine and Joint Center, P.C., Birmingham, Alabama, USA. jcuckler@charter.net

|September 16, 2010

Summary

Diagnosing painful total hip replacement (THR) involves identifying early issues like infection or mechanical problems, and late issues such as loosening or wear. Careful evaluation of symptoms and imaging is key for accurate diagnosis.

Area of Science:

Orthopedic surgery
Biomaterials science
Diagnostic imaging

Background:

Pain after total hip replacement (THR) can arise from various causes, both early and late.
Identifying the source of pain is crucial for effective patient management and revision surgery.
Metal-on-metal bearings present unique challenges, including hypersensitivity reactions.

Purpose of the Study:

To outline the differential diagnosis for painful total hip replacement (THR).
To describe the diagnostic workup for early and late causes of THR pain.
To emphasize the importance of a systematic approach to diagnosis.

Main Methods:

Detailed patient history, focusing on symptom comparison to preoperative state.
Radiographic review, including serial imaging to detect loosening.

Related Experiment Videos

Last Updated: Jun 8, 2026

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Laboratory tests (sedimentation rate, C-reactive protein) and joint aspiration for culture.

Advanced imaging such as Technetium bone scans and computed tomography (CT) scans.

Main Results:

Early THR pain causes include fixation failure, infection, instability, and soft tissue impingement.
Late THR pain causes involve loosening, wear, and late infections.
Metal-on-metal THR complications include hypersensitivity and osteolysis.
Differential diagnosis requires a comprehensive approach integrating clinical, radiographic, and laboratory findings.

Conclusions:

Accurate diagnosis of painful THR requires careful evaluation of history, imaging, and serologic tests.
Systematic diagnostic process is essential to avoid unnecessary interventions.
Identifying specific causes like psoas impingement or metal hypersensitivity guides treatment decisions.