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Updated: Jun 8, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
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Copper curcuminoids containing anthracene groups: fluorescent molecules with cytotoxic activity.

Núria Aliaga-Alcalde1, Patricia Marqués-Gallego, Mirte Kraaijkamp

  • 1Institut Català de Recerca i Estudis Avançats and Universitat de Barcelona, Facultat de Química, Martí i Franquès, 1-11, 08028 Barcelona, Spain. nuria.aliaga@icrea.cat

Inorganic Chemistry
|September 16, 2010
PubMed
Summary

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Researchers synthesized two novel copper-curcuminoid compounds, 9Accm, and studied their coordination chemistry and antitumor activity. DNA binding and cellular studies suggest interactions occur outside the cell nucleus.

Area of Science:

  • Coordination Chemistry
  • Inorganic Chemistry
  • Medicinal Chemistry

Background:

  • Curcuminoids are a class of compounds with diverse biological activities.
  • Copper complexes are of interest for their potential therapeutic applications.
  • The synthesis and characterization of novel metal-curcuminoid complexes are crucial for exploring new functionalities.

Purpose of the Study:

  • To synthesize and characterize new copper-curcuminoid complexes using a novel curcuminoid ligand, 9Accm.
  • To investigate the coordination chemistry and structural properties of the synthesized copper complexes.
  • To evaluate the antitumor activity and DNA-binding interactions of the novel compounds.

Main Methods:

  • Synthesis of copper-9Accm compounds: [Cu(phen)Cl(9Accm)] and [Cu(9Accm)(2)].

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  • Characterization using UV-vis, EPR, SQUID, and single-crystal X-ray diffraction.
  • Antitumor activity assessed against human tumor cell lines.
  • DNA interaction studies using UV-vis titration and Circular Dichroism.
  • Cellular localization studies using fluorescence microscopy.

    • Main Results:

    • Two novel copper-9Accm compounds were successfully synthesized and structurally characterized.
    • The compounds exhibited antitumor activity against various human tumor cells.
    • DNA-binding studies indicated weak electrostatic interactions with CT-DNA.
    • Fluorescence microscopy revealed that the compounds act outside the cell nucleus.

    Conclusions:

    • The study presents the first crystallographically described copper-curcuminoid complexes.
    • The synthesized compounds demonstrate potential as antitumor agents.
    • The compounds interact with DNA via weak electrostatic forces.
    • The mechanism of action appears to involve extranuclear cellular processes.