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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)
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Dalfampridine extended release: in multiple sclerosis.

Claudine M Chwieduk1, Gillian M Keating

  • 1Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz

CNS Drugs
|September 16, 2010
PubMed
Summary
This summary is machine-generated.

Dalfampridine extended release (ER) significantly improves walking speed in multiple sclerosis (MS) patients. This oral medication demonstrated sustained benefits and was well-tolerated in clinical trials.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting walking ability.
  • Dalfampridine extended release (ER) is a potassium channel antagonist developed to improve ambulation in MS patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral dalfampridine ER for improving walking ability in patients with MS.

Main Methods:

  • Three randomized, double-blind, placebo-controlled trials were conducted, including a Phase II trial and two Phase III trials.
  • Walking speed was assessed using the Timed 25-Foot Walk (T25FW) test.
  • Post hoc analyses and interim results from long-term extensions were also examined.

Main Results:

  • While not all initial endpoints were significant in Phase II, post hoc analysis revealed significantly higher response rates with dalfampridine ER.
  • Phase III trials showed a significantly greater proportion of timed walk responders with dalfampridine ER 10 mg twice daily compared to placebo.
  • Responders experienced a consistent mean improvement in walking speed of approximately 25% and sustained benefits for up to 2.5 years.

Conclusions:

  • Oral dalfampridine ER, particularly at 10 mg twice daily, is effective in improving walking speed in MS patients.
  • The treatment demonstrated sustained efficacy and was generally well-tolerated in the studied population.