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Effect of anaphylactic shock on suppressors of cytokine signaling

Zhenyu Li1, Yanbing Liang, Hao Tang

  • 1Department of General Internal Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Immunological Investigations
|September 16, 2010
PubMed

Insights

Anaphylactic shock mechanisms remain unclear. This study found increased SOCS1 and SOCS3 proteins and mRNA in organs like the kidney and liver, suggesting their role in anaphylactic shock organ injury.

Area of Science:

  • Immunology
  • Pathophysiology
  • Molecular Biology

Background:

  • The precise pathophysiologic mechanisms underlying anaphylactic shock are not fully understood.
  • Suppressor of Cytokine Signaling (SOCS) proteins, including SOCS1 and SOCS3, are critical regulators of immune responses.
  • Investigating SOCS1/SOCS3 expression may elucidate their role in anaphylactic shock-induced organ damage.

Purpose of the Study:

  • To investigate the expression and translation of SOCS1 and SOCS3 in visceral organs of patients who died from anaphylactic shock.
  • To compare SOCS1/SOCS3 levels with healthy controls to identify changes associated with anaphylactic shock.
  • To explore the potential involvement of SOCS1 and SOCS3 in the organ injury observed during anaphylactic shock.

Main Methods:

  • Analysis of visceral organ samples (heart, lungs, kidney, liver, spleen) from 8 anaphylactic shock fatalities and 8 accidental death controls.
  • Measurement of immunoglobulin E (IgE) levels in heart blood.
  • Determination of SOCS1/SOCS3 mRNA and protein expression using RT-PCR and immunohistochemistry, respectively.

Main Results:

  • Elevated IgE levels were detected in the heart blood of anaphylactic shock patients compared to controls.
  • Significant increases in SOCS1 and SOCS3 protein expression were observed in the kidney and liver.
  • Both SOCS1 and SOCS3 mRNA levels were elevated post-anaphylactic shock, with SOCS3 expression higher than SOCS1, particularly in the liver and kidney.

Conclusions:

  • SOCS1 and SOCS3 expression is altered in visceral organs following anaphylactic shock.
  • The increased expression of SOCS1 and SOCS3, especially in the liver and kidney, suggests a potential regulatory role in anaphylactic shock-induced organ injury.
  • Further research is warranted to fully elucidate the specific mechanisms by which SOCS1 and SOCS3 contribute to anaphylactic shock pathophysiology.

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