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Related Experiment Video

Updated: Jun 8, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Intrauterine inflammation and preterm delivery.

N Vrachnis1, N Vitoratos, Z Iliodromiti

  • 1Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, Athens, Greece. nvrachnis@med.uoa.gr

Annals of the New York Academy of Sciences
|September 16, 2010
PubMed
Summary

Chronic inflammation in amniotic fluid, triggered by bacteria or viruses, contributes to preterm birth and impacts infant health. Future interventions may involve immunomodulators to manage this maternofetal inflammatory response.

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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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Last Updated: Jun 8, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

  • Obstetrics and Gynecology
  • Neonatology
  • Developmental Biology

Background:

  • Spontaneous preterm delivery, prematurity, and low birth weight are major causes of neonatal morbidity and mortality.
  • Chronic amniotic fluid inflammation, potentially triggered by microbial or viral infections, is linked to preterm labor.
  • Intrauterine infection and inflammation are risk factors for adverse neurological outcomes in preterm infants.

Purpose of the Study:

  • To explore the role of chronic amniotic fluid inflammation in preterm birth.
  • To understand the pathophysiologic processes involved in intrauterine inflammation.
  • To identify potential future interventions for managing maternofetal inflammation.

Main Methods:

  • Review of epidemiological and experimental studies.
  • Application of molecular genetic techniques to understand pathophysiologic processes.
  • Analysis of mediators involved in the inflammatory response.

Main Results:

  • Chronic subclinical chorioamnionitis associated with preterm birth can affect lung development.
  • Molecular genetic techniques have improved understanding of intrauterine inflammation.
  • Various mediators contribute to the inflammatory response in amniotic fluid.

Conclusions:

  • Chronic intrauterine inflammation is a significant factor in preterm birth and adverse infant outcomes.
  • Understanding the molecular mechanisms of inflammation is crucial.
  • Immunomodulators represent a potential future therapeutic strategy for preterm embryos.