Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Amputation-free survival in the long-term follow-up and gender-related characteristics in patients revascularized for critical limb ischemia.

Journal de medecine vasculaire·2023

Same author

Evaluation of the ankle brachial index and toe brachial index for peripheral arterial disease diagnosis in patients over 70 years with lower limb ulcers.

Journal de medecine vasculaire·2023

Same author

Is aortic thrombosis an intruder in the COVID pandemic?

Journal de medecine vasculaire·2022

Same author

Peri-procedural complications following endovascular revascularization for critical limb ischemia.

Journal de medecine vasculaire·2022

Same author

Sequential intracorneal ring segment implantation followed by transepithelial phototherapeutic keratectomy and corneal cross-linking.

Journal francais d'ophtalmologie·2022

Same author

Incident cardiovascular events and early mortality in patients with revascularized critical limb ischemia.

Journal de medecine vasculaire·2022

Same journal

Contrast Media and Acute Kidney Injury in the ICU.

Acta anaesthesiologica Scandinavica·2026

Same journal

The Impact of Diuretics on Mortality in Acute Kidney Injury With or Without Fluid Accumulation in Intensive Care-A Retrospective Cohort Study.

Acta anaesthesiologica Scandinavica·2026

Same journal

Authors' Response to "Vasopressors in Early Burn Resuscitation: Physiological Concerns Revisited".

Acta anaesthesiologica Scandinavica·2026

Same journal

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE-A Cohort of 1.2 Million Surgeries.

Acta anaesthesiologica Scandinavica·2026

Same journal

Backrest Position and Outcome in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Protocol for a Multi-Center Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) Trial.

Acta anaesthesiologica Scandinavica·2026

Same journal

Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE).

Acta anaesthesiologica Scandinavica·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Rapid High Throughput Amylose Determination in Freeze Dried Potato Tuber Samples

Rapid High Throughput Amylose Determination in Freeze Dried Potato Tuber Samples

Published on: October 14, 2013

Maize- or potato-derived hydroxyethyl starches: is there any thromboelastometric difference?

A Godier¹, M Durand, D Smadja

¹Paris Descartes University, INSERM U, Paris, France. anne.godier@htd.aphp.fr

Acta Anaesthesiologica Scandinavica

|September 16, 2010

Summary

This summary is machine-generated.

Potato- and maize-derived hydroxyethyl starches (HES) similarly impact blood coagulation. Both HES solutions cause more severe hemostatic defects than crystalloids, primarily due to impaired fibrin polymerization.

More Related Videos

Analysis and Specification of Starch Granule Size Distributions

Analysis and Specification of Starch Granule Size Distributions

Published on: March 4, 2021

Molecular Entanglement and Electrospinnability of Biopolymers

Molecular Entanglement and Electrospinnability of Biopolymers

Published on: September 3, 2014

Related Experiment Videos

Last Updated: Jun 8, 2026

Rapid High Throughput Amylose Determination in Freeze Dried Potato Tuber Samples

Rapid High Throughput Amylose Determination in Freeze Dried Potato Tuber Samples

Published on: October 14, 2013

Analysis and Specification of Starch Granule Size Distributions

Analysis and Specification of Starch Granule Size Distributions

Published on: March 4, 2021

Molecular Entanglement and Electrospinnability of Biopolymers

Molecular Entanglement and Electrospinnability of Biopolymers

Published on: September 3, 2014

Area of Science:

Anesthesiology
Hematology
Pharmacology

Background:

Hydroxyethyl starches (HES) are volume expanders with varying origins.
The impact of HES raw material source on coagulation is not well understood.
This study compares potato-derived HES with maize-derived HES and crystalloids.

Purpose of the Study:

To compare the effects of potato-derived HES and maize-derived HES on blood coagulation.
To evaluate the impact of HES solutions versus crystalloids on hemostasis.
To identify the primary determinants of HES-induced coagulopathy.

Main Methods:

Whole blood from healthy individuals was diluted with potato-HES, maize-HES, saline, or Ringer's lactate.
Thromboelastometry (ROTEM) was used to assess coagulation parameters (INTEM, FIBTEM).
Platelet count and fibrinogen activity were measured.

Main Results:

No significant differences in coagulation effects were observed between potato- and maize-derived HES.
Hemostasis was impaired in a dose-dependent manner with all solutions.
HES solutions induced more severe hemostatic defects than crystalloids, particularly affecting fibrin polymerization.

Conclusions:

The origin of HES (potato vs. maize) does not influence its effect on coagulation.
Both HES preparations cause greater hemostatic impairment compared to crystalloids.
Impaired fibrin polymerization is a key factor in HES-induced coagulopathy.