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Updated: Jun 8, 2026
Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
Candida glabrata complicating in vitro pregnancy: successful management of subsequent pregnancy
Obehi A Asemota1, Paul Nyirjesy, Rachel Fox
1Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA. oasemota@drexelmed.edu
Objective:
To report the occurrence of Candida glabrata chorioamnionitis complicating an in vitro fertilization (IVF) pregnancy.
Design:
Case report.
Setting:
University hospital.
Patient(S):
A 30-year-old woman, primagravida, with an IVF dichorionic-diamniotic pregnancy who presented at 15 weeks with vaginal bleeding.
Intervention(S):
Before embryo transfer in next IVF cycle, vaginal culture from the patient revealed colonization with C. glabrata, which was treated with boric acid.
Main Outcome Measure(S):
Subsequent pregnancy after eradication of fungal organisms.
Result(S):
The patient's first pregnancy was treated with indomethacin and broad-spectrum antibiotics, but her membranes ruptured, and she delivered both twins at 16 weeks; the autopsy and pathology reports were consistent with C. glabrata chorioamnionitis. After boric acid treatment eradicated the organisms, two embryos were transferred in subsequent IVF treatment; the second pregnancy was uncomplicated, with dichorionic-diamniotic twins, delivered by cesarean section at 38 weeks.
Conclusion(S):
Eradication of vaginal colonization with C. glabrata may prevent infection of the next IVF pregnancy.
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