Domain recombination: a workhorse for evolutionary innovation
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Updated: Jun 8, 2026

Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
Gordana Apic1, Robert B Russell
1Cambridge Cell Networks, St John's Innovation Centre, Cowley Road, Cambridge CB4 OWS, UK.
Abstract:
Although the combination of modular domains within proteins has been proposed as a determining feature of evolutionary innovation and flexibility, direct evidence for this mechanism of evolution has been sketchy. Two papers, one creating new domain combinations in the yeast mating pathway and another involving a comprehensive analysis of protein function and domain architecture across major organisms, have provided firm evidence that the recombining of domains can lead to evolutionary innovation. The results will guide future studies in synthetic and evolutionary biology.
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