Value of weight reduction in patients with cardiovascular disease

Surya M Artham1, Carl J Lavie, Richard V Milani

  • 1Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.

Insights

Obesity significantly increases cardiovascular disease risk. This review covers exercise, medications, and surgery for obesity treatment and their cardiovascular benefits.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Obesity (BMI ≥30 kg/m²) is a major independent risk factor for cardiovascular (CV) disease.
  • It exacerbates conditions like hypertension, diabetes mellitus, and dyslipidemia.
  • Severe obesity (BMI ≥35 kg/m²) is linked to higher morbidity and mortality.

Purpose of the Study:

  • To review the obesity epidemic and its adverse effects on the cardiovascular system.
  • To discuss current and emerging therapeutic strategies for obesity management.
  • To evaluate the CV benefits and risks of pharmacologic and surgical interventions.

Main Methods:

  • Review of existing literature on obesity and cardiovascular health.
  • Analysis of exercise training protocols for weight management.
  • Examination of established and novel pharmacologic agents for obesity.
  • Evaluation of bariatric surgery outcomes and CV impact.

Main Results:

  • Physical activity, diet, and behavioral changes are foundational obesity treatments.
  • Limited pharmacologic options currently exist with proven efficacy and safety.
  • Bariatric surgery demonstrates significant CV benefits for select patients.

Conclusions:

  • Obesity poses a substantial threat to cardiovascular health.
  • A multi-faceted approach including lifestyle, pharmacotherapy, and surgery is crucial.
  • Careful consideration of risks and benefits is essential for pharmacologic and surgical obesity treatments.
Abstract

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