Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 8, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Newly diagnosed high-grade gliomas.

Pierre Giglio1, John Lee Villano

  • 1Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street CSB 306B, Charleston, SC, 29425, USA, giglio@musc.edu.

Current Treatment Options in Neurology
|September 16, 2010
PubMed
Summary

High-grade gliomas are aggressive brain cancers. Advances in radiation and chemotherapy, including temozolomide and bevacizumab, are improving survival, with ongoing research refining treatments for various glioma grades.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting acute neuronal responses to glioblastoma using a dual-interface human iPSC neuronal culture platform.

Acta neuropathologica communications·2026
Same author

Erratum: Evaluation of Regorafenib in Newly Diagnosed and Recurrent Glioblastoma: GBM AGILE Phase II/III Bayesian Randomized Platform Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Evaluation of Regorafenib in Newly Diagnosed and Recurrent Glioblastoma: GBM AGILE Phase II/III Bayesian Randomized Platform Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Boron Neutron Capture Therapy for High-Grade CNS Tumors: Mechanisms, Carriers, and Clinical Progress: A Narrative Review.

International journal of molecular sciences·2026
Same author

Tumor immunogenicity shapes CNS immune niches and CD8⁺ T cell fate in glioblastoma.

Journal of neuroinflammation·2026
Same author

Association of performance status, depression, and demographics with advance directive documentation in patients with glioblastoma.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Area of Science:

  • Neuro-oncology
  • Cancer Research
  • Oncology

Background:

  • High-grade gliomas (WHO grades III and IV) are aggressive primary brain tumors.
  • Symptoms include headaches, seizures, and focal neurological deficits.
  • Standard treatment involves surgery and radiation therapy, with chemotherapy evolving.

Purpose of the Study:

  • To review current treatment strategies for high-grade gliomas.
  • To discuss recent advances and ongoing research in neuro-oncology.
  • To highlight the evolving role of chemotherapy and targeted therapies.

Main Methods:

  • Review of current literature and clinical practices in high-grade glioma management.
  • Discussion of established and emerging treatment modalities.

More Related Videos

Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper
05:45

Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper

Published on: January 19, 2024

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
10:58

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Related Experiment Videos

Last Updated: Jun 8, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper
05:45

Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper

Published on: January 19, 2024

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
10:58

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

  • Analysis of ongoing clinical trials and future research directions.

    • Main Results:

    • Radiation therapy improves survival for malignant gliomas.
    • Concurrent temozolomide and radiation, plus bevacizumab, offer hope for glioblastoma (WHO grade IV).
    • The role of chemotherapy in grade III gliomas is under active investigation.

    Conclusions:

    • Improved outcomes and survival are leading to community oncologist management.
    • Pending investigations aim to refine temozolomide dosing, elderly treatment, and bevacizumab efficacy.
    • Further research is crucial to define chemotherapy's role in grade III gliomas and improve patient outcomes.