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Updated: Jun 8, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
Multipotent adipose stromal cells and breast cancer development: Think globally, act locally
Min Zhao1, Cathy I Dumur, Shawn E Holt
1Department of Pathology, Virginia Commonwealth University, Richmond, 23298, USA.
Abstract:
It has long been appreciated that stromal cells within the breast tumor microenvironment contribute to mammary carcinogenesis. However, to date, very little is known regarding the role of local adipose-derived stromal cells (ASCs) in the development of breast cancer. Based on pathological, epidemiological and experimental data, we postulate that breast-derived ASCs are unique mesenchymal stem-like cells that play a critical role in the development of breast cancer and discuss the global implications of this working model in terms of breast cancer prevention, early detection, and new targeted therapies.
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