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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

The p66shc gene expression in peripheral blood monocytes is increased in patients with coronary artery disease

Yoshihiro Noda1, Sho-ichi Yamagishi, Takanori Matsui

  • 1Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume, Japan.

Clinical Cardiology
|September 16, 2010
PubMed

Insights

Increased p66(shc) gene expression in peripheral blood monocytes (PBMs) is linked to coronary artery disease (CAD) in Japanese individuals. This finding suggests p66(shc) may serve as a novel biomarker for detecting CAD.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • The p66(shc) protein regulates cellular responses to oxidative stress and is implicated in atherosclerosis in animal models.
  • The association between p66(shc) gene expression and human coronary artery disease (CAD) has not been previously established.

Purpose of the Study:

  • To investigate whether p66(shc) gene expression is elevated in peripheral blood monocytes (PBMs) of patients with CAD compared to controls.
  • To determine if p66(shc) gene expression is an independent predictor of CAD.

Main Methods:

  • Quantitative real-time reverse transcription-polymerase chain reaction was used to measure p66(shc) gene expression levels in PBMs.
  • Uni- and multivariate analyses were performed to identify correlates of CAD in 40 Japanese subjects undergoing coronary angiography.
  • CAD was defined by >75% obstruction in a major coronary artery or prior percutaneous coronary intervention.

Main Results:

  • p66(shc) gene expression levels in PBMs were significantly higher in patients with CAD than in non-CAD subjects.
  • Multiple regression analysis indicated that p66(shc) gene expression and hypertension medication were independent predictors of CAD.
  • p66(shc) expression levels increased proportionally with the number of diseased coronary vessels.

Conclusions:

  • This study provides the first evidence that elevated p66(shc) gene expression in PBMs is independently associated with CAD in Japanese individuals.
  • p66(shc) gene expression in PBMs may represent a novel biomarker for the diagnosis of CAD in humans.
Abstract

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