Related Experiment Video

Updated: Aug 17, 2026

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

[Calcium antagonists in the treatment of nephrogenic hypertension]

I E Tareeva, I M Kutyrina, G M Galstian

    Klinicheskaia Meditsina
    |August 1, 1990
    PubMed

    Insights

    Calcium antagonists like nifedipine effectively lower blood pressure in patients with chronic glomerulonephritis and hypertension. These drugs did not negatively impact kidney function or fluid balance, making them a preferred choice.

    Area of Science:

    • Nephrology
    • Cardiology
    • Pharmacology

    Background:

    • Chronic glomerulonephritis frequently leads to arterial hypertension.
    • Managing hypertension in renal disease requires careful consideration of drug effects on renal hemodynamics and electrolytes.

    Purpose of the Study:

    • To evaluate the efficacy and safety of calcium antagonists (nifedipine, foridon, verapamil hydrochloride) as monotherapy in patients with chronic glomerulonephritis and hypertension.
    • To assess the impact of these agents on systemic and renal hemodynamics, water-electrolytic balance, and the renin-angiotensin system.

    Main Methods:

    • A study involving 46 patients with chronic glomerulonephritis and arterial hypertension.
    • Monotherapy with nifedipine, foridon, or verapamil hydrochloride was administered.
    • Evaluation of hypotensive effect, systemic and renal hemodynamics, water-electrolytic balance, and renin-angiotensin system activity.

    Main Results:

    • Nifedipine and foridon demonstrated peripheral vasodilator effects.
    • Nifedipine exhibited the most potent hypotensive effect.
    • No adverse effects on renal hemodynamics, intraglomerular pressure, renin-angiotensin system activation, or sodium/water retention were observed.

    Conclusions:

    • Calcium antagonists are a suitable treatment option for managing nephrogenic hypertension.
    • Nifedipine, foridon, and verapamil hydrochloride appear safe and effective in this patient population without compromising renal function.

    More Related Videos

    A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis08:21

    A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

    Published on: October 26, 2020

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion08:35

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

    Published on: May 26, 2022

    Related Concept Videos

    Antihypertensive Drugs: Action of Diuretics01:16

    Antihypertensive Drugs: Action of Diuretics

    Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various tubules...
    Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

    Antihypertensive Drugs: Potassium-Sparing Diuretics

    Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
    Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

    Antihypertensive Drugs: Action of Calcium Channel Blockers

    Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
    Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

    Antihypertensive Drugs: Angiotensin II Receptor Blockers

    In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
    Antihypertensive Drugs: Direct Renin Inhibitors01:25

    Antihypertensive Drugs: Direct Renin Inhibitors

    The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
    Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

    Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

    The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...