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Updated: Jun 8, 2026
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
IGVBrowser--a genomic variation resource from diverse Indian populations
Ankita Narang1, Rishi Das Roy, Amit Chaurasia
1GN Ramachandran Knowledge Centre for Genome Informatics, Institute of Genomics and Integrative Biology, Council for Scientific and Industrial Research, Mall Road, Delhi-110007, India.
Database : the Journal of Biological Databases and Curation
|September 17, 2010
Summary
The Indian Genome Variation Consortium (IGVC) project cataloged genetic variations in Indian populations. The IGVBrowser database now offers this data for studying diseases and drug responses.
Area of Science:
- Genomics
- Population Genetics
- Bioinformatics
Background:
- The Indian Genome Variation Consortium (IGVC) project is the first large-scale study of genetic diversity within the Indian population.
- It aims to catalog variations in genes related to diseases and drug response for predictive marker discovery and understanding ethnic diversity.
Purpose of the Study:
- To report the development of the IGVBrowser, a database providing allele and genotype frequency data from the IGVC project.
- To make this variation data accessible for research on Indian populations.
Main Methods:
- Collected data on 4229 Single Nucleotide Polymorphisms (SNPs) from over 900 candidate genes across diverse Indian populations.
- Incorporated approximately 50,000 genome-wide neutral markers (Affy 50K array) for reference populations.
- Developed the IGVBrowser to host and analyze this genomic variation data.
Main Results:
- The IGVBrowser database contains variation data for 4229 SNPs from >900 candidate genes in Indian populations.
- Most identified markers are located in genic regions, with a significant fraction linked to cardiovascular, metabolic, cancer, and immune system diseases.
- The database also includes genome-wide neutral markers for the reference populations.
Conclusions:
- The IGVC data, accessible via IGVBrowser, provides a foundational resource for studying genetic diseases and pharmacology in the Indian population.
- The browser allows comparison of Indian genomic variations with global data (e.g., HapMap) and includes annotation information.
- This resource aids in understanding genetic diversity, migration patterns, and population relatedness.
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