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Related Experiment Video

Updated: Jun 8, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Quantitative MR imaging of brain iron: a postmortem validation study.

Christian Langkammer¹, Nikolaus Krebs, Walter Goessler

¹Department of Neurology and Division of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.

|September 17, 2010

Summary

This summary is machine-generated.

Transverse relaxation rates R2 and R2* accurately measure brain iron concentration. R2* is preferred for in vivo assessment due to higher sensitivity and ability to detect white matter iron differences.

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High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

Published on: December 30, 2015

Area of Science:

Neuroimaging
Biomarkers
Iron Metabolism

Background:

Iron is crucial for brain function but its dysregulation is implicated in neurological disorders.
Quantitative Magnetic Resonance (MR) imaging techniques are vital for non-invasively assessing brain tissue properties.
Transverse relaxation rates, R2 and R2*, are frequently used as surrogate markers for brain iron concentration.

Purpose of the Study:

To investigate the relationship between transverse relaxation rates (R2 and R2*) and chemically determined iron concentrations in human postmortem brain tissue.
To evaluate the utility of R2 and R2* as reliable markers for quantifying brain iron deposition.

Main Methods:

Quantitative MR imaging at 3.0 T was performed on seven human postmortem brains.
Iron concentrations were chemically determined using inductively coupled plasma mass spectrometry in gray and white matter regions.
Linear regression analysis was used to correlate relaxation rates (R2, R2*) with iron concentrations.

Main Results:

Strong linear correlations were observed between R2 and iron concentration (r² = 0.67) and R2* and iron concentration (r² = 0.90) across all brain tissues.
R2* showed a significant linear correlation with iron concentration in white matter, whereas R2 did not.
While chemical analysis revealed hemispheric differences in iron concentration, these were not reflected in the relaxation rates.

Conclusions:

Both R2 and R2* are validated as reliable measures of brain iron deposition.
R2* is recommended as the preferred parameter for in vivo assessment of brain iron due to its superior sensitivity and ability to detect white matter iron differences.