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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cross-reactivity00:42

Cross-reactivity

Overview
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Updated: Jun 8, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

CD8 controls T cell cross-reactivity.

Linda Wooldridge1, Bruno Laugel, Julia Ekeruche

  • 1Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK. wooldridgel@cardiff.ac.uk

Journal of Immunology (Baltimore, Md. : 1950)
|September 17, 2010
PubMed
Summary
This summary is machine-generated.

T cell receptors (TCRs) exhibit high cross-reactivity to recognize diverse antigens. The CD8 coreceptor regulates this cross-reactivity for peptide-MHC class I (pMHCI) antigens, balancing T cell responses to danger and self-tolerance.

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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Last Updated: Jun 8, 2026

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Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
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Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • T cell receptors (TCRs) recognize peptide-MHC (pMHC) complexes.
  • The diversity of TCRs is limited compared to the vast array of potential pMHC molecules.
  • T cell recognition involves TCRs and coreceptors, such as CD8, which bind distinct sites on pMHC.

Purpose of the Study:

  • To investigate the role of the CD8 coreceptor in controlling T cell cross-reactivity.
  • To understand how CD8 influences the T cell repertoire's ability to respond to foreign antigens while maintaining self-tolerance.

Main Methods:

  • The study likely involved experiments assessing T cell activation and binding in response to various pMHCI antigens.
  • Methods may include in vitro assays, flow cytometry, and potentially structural biology techniques.

Main Results:

  • The CD8 coreceptor was found to control T cell cross-reactivity specifically for peptide-MHC class I (pMHCI) antigens.
  • This regulation by CD8 ensures the peripheral T cell repertoire is balanced for effective responses and self-tolerance.

Conclusions:

  • CD8 coreceptor plays a critical role in modulating T cell cross-reactivity to pMHCI.
  • This mechanism is essential for maintaining immune homeostasis, allowing T cells to respond to threats without causing autoimmunity.