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Updated: Jun 8, 2026
Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
Heterogeneity of IL-22-producing Lymphoid Tissue Inducer-like Cells in Human and Mouse
Soochan Kim1, Sinsuk Han, Mi-Yeon Kim
1Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea.
Lymphoid tissue inducer (LTi) cells have been characterized in mouse as a key cell when secondary lymphoid tissues are organized during development and memory T cells are formed after birth. In addition to their involvement in adaptive immune responses, recent studies show that they contribute to innate immune responses by producing large amount of interleukin (IL)-22 against microbial attack. Here, we compare IL-22-producing LTi and LTi-like cells in human and mouse and discuss their heterogeneity in different tissues.
Lymphoid tissue inducer (LTi) cells have been characterized in mouse as a key cell when secondary lymphoid tissues are organized during development and memory T cells are formed after birth. In addition to their involvement in adaptive immune responses, recent studies show that they contribute to innate immune responses by producing large amount of interleukin (IL)-22 against microbial attack. Here, we compare IL-22-producing LTi and LTi-like cells in human and mouse and discuss their heterogeneity in different tissues.
