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Related Experiment Video

Updated: Jun 8, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Cpd-1 null mice display a subtle neurological phenotype.

Rupinder K Kular1, Rocky G Gogliotti, Puneet Opal

  • 1Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

Plos One
|September 17, 2010
PubMed
Summary

CPD1 (also known as ANP32-E) is not essential for development, but its absence causes mild motor deficits in mice. This suggests CPD1 regulates fine motor functions, with compensatory mechanisms at play.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • CPD1 (ANP32-E) is an acidic protein family member involved in gene expression, signaling, and apoptosis.
  • Its expression pattern suggests a role in brain and synaptic development.

Purpose of the Study:

  • To investigate the function of CPD1 in vivo.
  • To characterize the neurological and developmental roles of CPD1.

Main Methods:

  • Generation of CPD1 knock-out mice.
  • Phenotypic characterization of the knock-out mice, including neurological and motor assessments.

Main Results:

  • CPD1 knock-out mice are viable and fertile.
  • These mice exhibit a subtle neurological clasping phenotype and mild motor deficits.

Conclusions:

  • CPD1 is not essential for overall development.
  • CPD1 plays a role in regulating fine motor functions.
  • The subtle phenotype indicates potential compensatory biological mechanisms in CPD1-deficient mice.