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Updated: Jun 8, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Interaction of Amphotericin B with cholesteryl palmityl carbonate ester
Rabkwan Chuealee1, Timothy S Wiedmann, Roongnapa Suedee
1Department of Pharmaceutical Technology and Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai Songkla 90112, Thailand.
Abstract:
A cholesteryl carbonate ester was prepared and evaluated as a possible thermotropic liquid crystal excipient for dry powder inhalers. Cholesteryl palmityl carbonate (CPC) was synthesized, and the phase behavior was characterized by differential scanning calorimetry, transmission electron microscopy, polarized light microscope, small angle X-ray diffraction, and solid-state nuclear magnetic resonance spectroscopy. Amphotericin B (AmB) was incorporated into CPC at various mole% (7.7, 14.3, 25, 33.3, and 50) using a solvent evaporation method. The amount of AmB loaded into liquid crystal was limited. The mixture of AmB in liquid crystal did not produce a new complex; rather, the addition of AmB affected the orientational order and the motional aspects of liquid crystal molecules.
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