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Updated: Jun 8, 2026

Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells
Published on: June 3, 2012
[Mechanisms of influenza virus replication]
Takeshi Noda1, Yoshihiro Kawaoka
1International Research Center for Infectious Diseases.
Abstract:
The influenza A virus genome consists of eight, single-stranded, negative-sense RNA segments. Unlike most negative-sense RNA viruses, transcription and replication of the influenza A virus genome occurs in the nucleus of cells. Once synthesized, the genomic RNA is exported to the cytoplasm and then to the apical plasma membrane, where a complete set of the eight viral RNA segments is packaged into progeny virions. Here, we discuss the influenza A virion structure and its replication steps in host cells.
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