[Current anti-influenza virus chemotherapy]
Daisuke Yoshioka1, Issei Tokimatsu, Hiroshi Ishii
1Internal Medicine II, Oita University, Faculty of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 18, 2010
Summary
Pandemic H1N1 influenza requires careful drug selection. Amantadine is ineffective, while oseltamivir resistance is a growing concern, necessitating monitoring of antiviral efficacy.
Area of Science:
- Virology
- Epidemiology
- Infectious Diseases
Background:
- The global influenza landscape is evolving, marked by the 2009 pandemic (H1N1).
- Effective influenza control is crucial worldwide.
- Antiviral drug resistance presents a significant challenge to public health.
Purpose of the Study:
- To review the current status of antiviral drugs for influenza in Japan.
- To highlight the emergence of drug-resistant influenza strains.
- To inform clinical practice regarding appropriate antiviral selection.
Main Methods:
- Literature review of antiviral drug efficacy and resistance patterns.
- Analysis of available anti-influenza medications in Japan.
- Discussion of clinical recommendations for pandemic (H1N1) 2009 and seasonal influenza.
Main Results:
- Amantadine is ineffective against pandemic (H1N1) 2009 due to widespread resistance.
- Oseltamivir is widely used but resistance is emerging.
- Zanamivir exhibits low resistance rates; peramivir offers an intravenous option for severe cases.
Conclusions:
- Antiviral resistance necessitates ongoing surveillance and strategic drug use.
- Oseltamivir resistance is a key concern for pandemic (H1N1) 2009 management.
- Peramivir provides a valuable therapeutic option for severe influenza infections.
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