Related Experiment Videos
Psoriasis: from pathogenesis to novel therapeutic approaches
Giovanni Monteleone1, Francesco Pallone, Thomas T MacDonald
1Gastroenterology Unit, Internal Medicine Department, University Tor Vergata of Rome, 00133 Rome, Italy. gi.monteleone@med.uniroma2.it
Clinical Science (London, England : 1979)
|September 18, 2010
Summary
Psoriasis is a chronic inflammatory skin disease caused by genetic and environmental factors. Understanding its immunology, involving dendritic cells and T-cells, has improved patient management and led to new therapies.
Area of Science:
- Dermatology and Immunology
Background:
- Psoriasis is a prevalent chronic inflammatory skin disorder.
- Its etiology involves a complex interplay of genetic predisposition and environmental triggers.
- The pathogenesis is characterized by an excessive immune response in the skin.
Purpose of the Study:
- To elucidate the immunological mechanisms underlying psoriasis plaque formation.
- To highlight the role of specific immune cells and cytokines in disease development.
- To discuss the impact of immunological insights on therapeutic strategies for psoriasis.
Main Methods:
- Review of existing literature on psoriasis immunology.
- Analysis of the roles of dendritic cells and effector T-cells.
- Examination of cytokine signaling pathways and their effects on keratinocytes.
Main Results:
- Dendritic cells and effector T-cells are key players in psoriatic lesion development.
- Cytokines produced by immune cells drive keratinocyte proliferation and inflammation.
- This understanding facilitates the development of targeted immunomodulatory therapies.
Conclusions:
- A comprehensive understanding of psoriasis immunology is crucial for effective patient management.
- Advances in understanding the psoriatic plaque have opened avenues for novel immunomodulatory treatments.
- The management of psoriasis has been significantly advanced by immunological research.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:21EPS and iPS Cells in Disease Research
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...