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Related Experiment Video

Updated: Jun 8, 2026

Activating Autophagy by Aerobic Exercise in Mice

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

Physical exercise activates the poly(ADP-ribosyl)ation system in rat testes.

M R Faraone-Mennella¹, M Marini, A Ferone

¹Department of Structural and Functional Biology, University of Naples, Federico II, Naples, Italy.

Journal of Biological Regulators and Homeostatic Agents

|September 18, 2010

Summary

Treadmill training and acute exercise in rats marginally increased germ cell apoptosis. Exercise activates the poly(ADP-ribosyl)ation system, suggesting reversible genotoxic stress from acute exercise and adaptive responses to training.

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Published on: August 22, 2014

Area of Science:

Reproductive Biology
Exercise Physiology
Toxicology

Background:

The male reproductive system is sensitive to oxidative stress and temperature.
Genotoxic stress can impact germ cell health and function.
The poly(ADP-ribosyl)ation system is a sensitive biomarker for genotoxic stress.

Purpose of the Study:

To evaluate germ cell apoptosis and poly(ADP-ribosyl)ation system activation in rat testes after treadmill training.
To differentiate the effects of mild vs. strong training protocols and acute exercise.
To assess adaptive responses to exercise-induced stress in the male reproductive system.

Main Methods:

Adult rats underwent 10-week treadmill training (mild or strong protocols).
Testicular tissue was analyzed 24 hours post-training or after acute swimming exercise.
Germ cell apoptosis was measured via caspase-induced poly(ADP-ribose) polymerase fragmentation and TUNEL assay.
Poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase enzyme activities were assessed.

Main Results:

Both training and acute exercise marginally increased germ cell apoptotic indexes.
Acute exercise was associated with reversible genotoxic stress, indicated by enzyme activity changes.
Treadmill training induced adaptive responses, activating the poly(ADP-ribose) polymerase system without increasing apoptosis.

Conclusions:

Exercise, particularly acute bouts, can induce transient genotoxic stress in the male reproductive system.
Chronic treadmill training promotes adaptive mechanisms, mitigating exercise-induced germ cell apoptosis.
The poly(ADP-ribosyl)ation system is a valuable indicator of stress and adaptation in testicular tissue during exercise regimes.