Related Experiment Video
Updated: Jun 8, 2026
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
[Susac syndrome: variable onset modes and disease courses: two case reports]
H El Chehab1, A Le Corre, G Ract-Madoux
1Service d'ophtalmologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69003 Lyon, France. elchehab_hussam@hotmail.fr
Journal Francais D'Ophtalmologie
|September 18, 2010
Summary
Susac syndrome, a rare microangiopathy, affects young women with encephalopathy, visual, and hearing loss. Early neurological symptoms guide therapeutic decisions for this condition.
Area of Science:
- Neurology
- Ophthalmology
- Otorhinolaryngology
Background:
- Susac syndrome is a rare microangiopathy of unknown cause.
- It presents with a triad of encephalopathy, visual loss, and hearing loss.
- The syndrome can manifest with various onset and progression patterns.
Observation:
- Two cases are presented: a 43-year-old woman with subacute encephalopathy and hearing loss, and a 27-year-old woman with recurrent neurological episodes and visual loss.
- Ophthalmic findings included retinal artery branch occlusion.
- Both patients experienced sensorineural hearing loss.
Findings:
- Susac syndrome predominantly affects young women.
- Neurological symptoms are common and varied, often preceding ophthalmic and ENT manifestations.
- Characteristic MRI findings include corpus callosum lesions; branch occlusions and vasculitis are frequent.
Implications:
- Diagnosis relies on the neurological, ophthalmic, and ENT triad, though symptom chronology can complicate it.
- Prompt recognition of neurological damage is crucial for treatment decisions.
- Treatment typically involves corticosteroids and immunosuppressants for severe cases.
Related Concept Videos
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:30Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...