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Updated: Jun 8, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Published on: December 9, 2015

[Susac syndrome: variable onset modes and disease courses: two case reports].

H El Chehab1, A Le Corre, G Ract-Madoux

  • 1Service d'ophtalmologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69003 Lyon, France. elchehab_hussam@hotmail.fr

Journal Francais D'Ophtalmologie
|September 18, 2010
PubMed
Summary

Susac syndrome, a rare microangiopathy, affects young women with encephalopathy, visual, and hearing loss. Early neurological symptoms guide therapeutic decisions for this condition.

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Last Updated: Jun 8, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

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Published on: December 9, 2015

Area of Science:

  • Neurology
  • Ophthalmology
  • Otorhinolaryngology

Background:

  • Susac syndrome is a rare microangiopathy of unknown cause.
  • It presents with a triad of encephalopathy, visual loss, and hearing loss.
  • The syndrome can manifest with various onset and progression patterns.

Observation:

  • Two cases are presented: a 43-year-old woman with subacute encephalopathy and hearing loss, and a 27-year-old woman with recurrent neurological episodes and visual loss.
  • Ophthalmic findings included retinal artery branch occlusion.
  • Both patients experienced sensorineural hearing loss.

Findings:

  • Susac syndrome predominantly affects young women.
  • Neurological symptoms are common and varied, often preceding ophthalmic and ENT manifestations.
  • Characteristic MRI findings include corpus callosum lesions; branch occlusions and vasculitis are frequent.

Implications:

  • Diagnosis relies on the neurological, ophthalmic, and ENT triad, though symptom chronology can complicate it.
  • Prompt recognition of neurological damage is crucial for treatment decisions.
  • Treatment typically involves corticosteroids and immunosuppressants for severe cases.