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Related Experiment Video

Updated: Jun 8, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Multidrug encapsulation by coaxial tri-capillary electrospray.

Yi-Hsuan Lee¹, Meng-Yi Bai, Da-Ren Chen

¹Department of Energy, Environmental and Chemical Engineering, Washington University, St. Louis, MO 63130, United States.

Colloids and Surfaces. B, Biointerfaces

|September 18, 2010

Summary

A novel tri-capillary electrospray system synthesizes multi-drug PLGA-coated particles in one step. This method allows controlled release of multiple drugs from distinct particle layers, offering advanced drug delivery potential.

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Published on: April 23, 2019

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

Materials Science
Nanotechnology
Pharmaceutical Sciences

Background:

Conventional methods for creating multi-drug particles are complex and involve multiple steps.
Controlling the release kinetics of multiple encapsulated drugs remains a significant challenge in drug delivery.

Purpose of the Study:

To develop a streamlined method for synthesizing monodisperse, multi-drug-loaded particles with a tri-layered structure.
To investigate the drug encapsulation efficiency and release profiles of these novel particles.

Main Methods:

Utilized a coaxial tri-capillary electrospray (ES) system for one-step particle synthesis.
Characterized particle size, structure, and drug encapsulation using Scanning Electron Microscopy (SEM) and Laser Scanning Confocal Microscopy (LSCM).
Compared drug release profiles of tri-layered particles with core-shell particles produced via dual-capillary ES.

Main Results:

Achieved nearly 100% drug encapsulation efficiency with the tri-capillary ES system.
Demonstrated control over particle size (submicrometer to micrometer) and layer thickness by adjusting spray parameters.
Tri-layered particles exhibited distinct kinetic phases for multi-drug release, controllable by layer properties.

Conclusions:

The coaxial tri-capillary ES system offers an efficient method for fabricating multi-drug PLGA-coated particles.
Tri-layered composite particles enable tunable, sequential release of multiple drugs, advancing controlled drug delivery systems.
This technique provides a versatile platform for developing advanced pharmaceutical formulations.