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Updated: Jun 8, 2026

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
Published on: October 13, 2022
Importance of the caspase cleavage site in amyloid-β protein precursor
Dale E Bredesen1, Varghese John, Veronica Galvan
1Buck Institute for Age Research, Novato, CA 94945, USA. dbredesen@buckinstitute.org
Abstract:
Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-β protein precursor (AβPP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in AβPP.
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