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Updated: Jun 8, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in
Vincent C T Mok1, Adrian Wong, Kelvin Wong
1Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, China. vctmok@cuhk.edu.hk
Background/Aims:
This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH).
Methods:
The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms.
Results:
Seventy-seven stroke patients (mean WMH volume: 39.5 cm(3)) were recruited. Thirty patients (39%) had ≥ 1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression.
Conclusion:
Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.
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