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Updated: Jun 8, 2026
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma
Takuo Haruyama1, Masayuki Furukawa, Takeshi Kusunoki
1Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan.
Purpose:
The present study was designed to elucidate the immunoreactivity and protein level of IL-17 in human cholesteatomas.
Procedures:
The expression and localization of IL-17 and receptor activator of nuclear factor κB ligand (RANKL) were examined by immunohistochemistry in tissue specimens collected from 24 patients with cholesteatomas. The cellular sources of IL-17 were assessed by double staining with CD4. The level of IL-17 protein was determined using an enzyme-linked immunosorbent assay. The degree of bone destruction was compared with the IL-17 immunoreactivity.
Results:
IL-17 immunoreactivity was detected in the inflammatory cells in the granulation tissues and there were increased levels of IL-17 protein. The localization of IL-17 expression coincided with CD4-positive lymphocytes. IL-17 was correlated with the cells positive for RANKL. The degree of bone destruction was dependent on the number of infiltrated IL-17-positive cells. IL-17-driven pathology was observed in the congenital type as compared with the acquired type.
Conclusions:
The present study suggests that IL-17 is related to the pathogenesis of the disease.
