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Related Experiment Video

Updated: Jun 8, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Ripple/Carcinoid pattern sebaceoma with apocrine differentiation.

Noriyuki Misago¹, Yutaka Narisawa

¹Department of Internal Medicine, Saga University, Japan. misago@post.saga-med.ac.jp

The American Journal of Dermatopathology

|September 18, 2010

Summary

Sebaceoma, a benign skin tumor, can exhibit unique growth patterns and apocrine differentiation. Tumors with a ripple/carcinoid pattern may originate from more primitive cells, suggesting a unified growth pattern.

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Last Updated: Jun 8, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Area of Science:

Dermatopathology
Oncology
Histopathology

Background:

Sebaceoma is a benign neoplasm originating from sebaceous glands.
Characteristic growth patterns include ripple, labyrinthine/sinusoidal, and carcinoid-like.
Recent observations suggest potential apocrine differentiation within sebaceoma.

Observation:

This report details a case of carcinoid pattern sebaceoma (partially ripple and labyrinthine) exhibiting apocrine differentiation.
Immunohistochemical studies were performed to investigate the cellular origins and differentiation pathways.

Findings:

The study proposes a unified term, "ripple/carcinoid pattern," to encompass the various observed growth patterns, suggesting they are variations of a single cord-like arrangement.
The presence of apocrine differentiation indicates that primitive sebaceous germinative cells within sebaceoma retain multipotent differentiation capabilities.
A correlation was observed between the ripple/carcinoid growth pattern and apocrine differentiation in most reported cases, including this one.

Implications:

Ripple/carcinoid pattern sebaceoma may be composed of more primitive sebaceous germinative cells compared to conventional sebaceoma.
Understanding these differentiation pathways aids in accurate diagnosis and classification of sebaceous neoplasms.
Further research into the developmental biology of sebaceous glands could elucidate the origins of these diverse patterns.