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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Inflammation, a link between obesity and cardiovascular disease
Zhaoxia Wang1, Tomohiro Nakayama
1Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Ooyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Mediators of Inflammation
|September 18, 2010
Summary
Obesity, a common nutritional disorder, is linked to chronic inflammation and increased cardiovascular disease (CVD) risk. This review explores the connection between obesity, inflammation, and CVD, focusing on key adipokines.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Nutritional Science
Background:
- Obesity is a prevalent nutritional disorder linked to increased cardiovascular disease (CVD) mortality and morbidity.
- Emerging evidence suggests a connection between obesity and chronic low-grade inflammation.
- This paper reviews the interplay between obesity, inflammation, and CVD.
Purpose of the Study:
- To summarize current knowledge on the link between chronic inflammation and obesity-related CVD.
- To discuss methods for body fat evaluation and adipose tissue endocrinology.
- To explore the role of specific adipokines in inflammation and CVD.
Main Methods:
- Literature review focusing on obesity, inflammation, and cardiovascular disease.
- Discussion of body fat assessment techniques.
- Analysis of adipose tissue-derived cytokines (adipokines).
Main Results:
- Obesity is associated with chronic inflammation, contributing to CVD development.
- Adipose tissue plays an endocrine role, releasing cytokines that influence inflammation.
- Specific adipokines like C-reactive protein, leptin, and adiponectin are implicated.
Conclusions:
- Chronic inflammation is a key mediator linking obesity to cardiovascular diseases.
- Understanding adipokine function is crucial for managing obesity-related CVD.
- Further research into adipokines may reveal novel therapeutic targets.
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