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07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Hyperfunctioning solid/trabecular follicular carcinoma of the thyroid gland
Luca Giovanella1, Fabrizio Fasolini, Sergio Suriano
1Department of Nuclear Medicine and PET-CT Centre, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland.
Journal of Oncology
|September 18, 2010
Summary
This paper reports the first case of a hyperfunctioning follicular solid/trabecular carcinoma within a thyroid nodule. Early detection is crucial to avoid overlooking malignancy in hot thyroid nodules.
Area of Science:
- Endocrinology
- Oncology
- Nuclear Medicine
Background:
- Follicular thyroid carcinoma (FTC) is a common thyroid malignancy.
- Hyperfunctioning thyroid nodules, typically benign, can rarely harbor malignancy.
Observation:
- A 68-year-old woman presented with neck swelling and tachycardia.
- Ultrasonography revealed a hypoechoic nodule; (99m)Tc-pertechnetate scan showed a hyperfunctioning nodule despite suppressed TSH.
- Histopathology confirmed solid/trabecular follicular thyroid carcinoma.
Findings:
- This is the first reported case of a hyperfunctioning follicular solid/trabecular carcinoma.
- The malignancy was found within an autonomously functioning thyroid nodule.
Implications:
- Hyperfunctioning thyroid nodules require careful evaluation to rule out malignancy.
- This rare presentation highlights the importance of considering cancer in seemingly benign "hot" nodules.
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