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Updated: Jun 8, 2026
09:35
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Diabetes mellitus, acute hyperglycemia, and ischemic stroke
Askiel Bruno1, David Liebeskind, Qing Hao
1Department of Neurology, Medical College of Georgia, 1120 15th Street, BI3076, Augusta, GA, 30912, USA, abruno@mcg.edu.
Current Treatment Options in Neurology
|September 18, 2010
Summary
Hyperglycemia during acute brain ischemia worsens injury. Less aggressive subcutaneous insulin treatments may be appropriate, but rapid correction is advised for severe cases, especially before thrombolytic therapy.
Area of Science:
- Neuroscience
- Endocrinology
- Critical Care Medicine
Background:
- Acute brain ischemia is influenced by blood glucose levels.
- Hyperglycemia exacerbates brain injury during ischemic events.
- Evidence from randomized trials on correcting hyperglycemia is lacking.
Purpose of the Study:
- To evaluate the clinical efficacy of correcting hyperglycemia in acute brain ischemia.
- To determine appropriate insulin treatment strategies for hyperglycemic stroke patients.
Main Methods:
- Review of animal and clinical observational studies.
- Discussion of less aggressive subcutaneous insulin protocols.
- Consideration of intravenous insulin for severe hyperglycemia, particularly before thrombolysis.
Main Results:
- Subcutaneous insulin protocols can maintain blood glucose below 200 mg/dL.
- Rapid correction may be beneficial for severe hyperglycemia (approx. 300 mg/dL) prior to thrombolytic therapy.
- Intravenous insulin bolus and infusion can effectively lower and maintain glucose levels.
Conclusions:
- Less aggressive subcutaneous insulin treatments are generally appropriate.
- Rapid correction of severe hyperglycemia is recommended for patients receiving thrombolytic therapy.
- Endocrinology consultation can optimize acute treatment and long-term care transition.
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