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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

NF-κB and innate immunity.

Anurupa Dev1, Shankar Iyer, Bahram Razani

  • 1Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, 615 Charles Young Dr S., 210A BSRB, Los Angeles, CA 90095, USA.

Current Topics in Microbiology and Immunology
|September 18, 2010
PubMed
Summary
This summary is machine-generated.

The NF-κB pathway is crucial for innate immunity, controlling cytokine expression and cellular responses to pathogens. This review explores NF-κB activation, pathogen modulation, and its impact on immune system function.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • The NF-κB transcription factor family is essential for innate immunity.
  • Activation occurs via pattern recognition receptors in response to pathogens or tissue damage.
  • NF-κB regulates downstream cytokine expression and signal transduction.

Purpose of the Study:

  • To review signaling pathways of NF-κB activation in innate immunity.
  • To examine pathogen modulation of NF-κB pathways.
  • To discuss NF-κB-dependent gene programs and consequences of subunit absence.

Main Methods:

  • Literature review of signaling pathways.
  • Analysis of pathogen interaction with NF-κB.
  • Examination of gene expression data.
  • Review of immunological studies on NF-κB subunit deficiencies.

Main Results:

  • NF-κB is activated by Toll-like receptors, RIG-I-like helicases, and NOD proteins.
  • NF-κB controls diverse cellular processes, including apoptosis and cell survival.
  • Pathogens can modulate NF-κB signaling to evade immune responses.

Conclusions:

  • NF-κB plays a central role in orchestrating innate immune responses.
  • Understanding NF-κB modulation by pathogens is key to developing immune therapies.
  • Deficiencies in NF-κB subunits have significant physiological consequences for immunity.